Chloroacetic Acid → HCID 18779028, compound

HRID 1457039Notes

Reaction equation

HRID 1457039 reaction equation
[H-].[Na+].[CH3:3][C:4]1[S:8][C:7]([CH2:9][CH2:10][OH:11])=[CH:6][CH:5]=1.Cl[CH2:13][C:14]([OH:16])=[O:15]>CN(C)C=O>[CH3:3][C:4]1[S:8][C:7]([CH2:9][CH2:10][O:11][CH2:13][C:14]([OH:16])=[O:15])=[CH:6][CH:5]=1

Participants

5

Reactant 3

HCID 300Chloroacetic AcidHCID 24758Sodium hydrideHCID 1328928919498-70-5

Product 1

HCID 18779028HCID 18779028, compoundYield 107.3%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent3×

Procedure

Sodium hydride (0.622 g) was suspended in dry dimethylformamide (5 ml) and treated dropwise with a solution of 2-(5-methyl-2-thienyl)ethanol (1.0 g) in dry dimethylformamide (5 ml). The mixture was stirred at room temperature under nitrogen for 2 hours then a solution of chloroacetic acid (0.664 g) in dry dimethylformamide (5 ml) added. The mixture was stirred at room temperature overnight. The volatiles were removed in vacuo and the residue quenched with water and extracted with ethyl acetate. The aqueous layer was adjusted to pH 2 using dilute hydrochloric acid and then extracted with ethyl acetate. This extract was washed with water, brine then dried (MgSO4). The solvent was removed in vacuo to give a brown oil (1.51 g) which was used without further purification.

Workup

  1. stirringThe mixture was stirred at room temperature overnight
  2. customThe volatiles were removed in vacuo
  3. customthe residue quenched with water
  4. extractionextracted with ethyl acetate
  5. extractionextracted with ethyl acetate
  6. washThis extract was washed with water, brine
  7. dry with materialthen dried (MgSO4)
  8. customThe solvent was removed in vacuo

Sources & evidence

ORD record
ord-40bb44d5736a4221b15f45c446b95a8c
Source dataset
uspto-grants-1998_12
Patent number
US05846989

Reaction notes

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