Isonicotinoyl chloride hydrochloride → HCID 15428633, compound

HRID 1457064Notes

Reaction equation

HRID 1457064 reaction equation
[CH3:1][N:2]([CH3:24])[CH:3]1[CH2:23][CH2:22][C:6]2[O:7][C:8]3[CH:13]=[CH:12][C:11]([NH:14][C:15]([O:17]C(C)(C)C)=O)=[CH:10][C:9]=3[C:5]=2[CH2:4]1.Cl.C(Cl)(=O)[C:27]1[CH:32]=[CH:31][N:30]=[CH:29][CH:28]=1>>[CH3:24][N:2]([CH3:1])[CH:3]1[CH2:23][CH2:22][C:6]2[O:7][C:8]3[CH:13]=[CH:12][C:11]([NH:14][C:15]([C:27]4[CH:32]=[CH:31][N:30]=[CH:29][CH:28]=4)=[O:17])=[CH:10][C:9]=3[C:5]=2[CH2:4]1

Participants

3

Reactant 2

HCID 12262826Isonicotinoyl chloride hydrochlorideHCID 21221611HCID 21221611, compound

Product 1

HCID 15428633HCID 15428633, compoundYield 36%

Procedure

Beginning with 0.100 gm (0.30 mMol) of (+)-N,N-dimethyl-8-(tert-butoxycarbonyl)amino-1,2,3,4-tetrahydro-2-dibenzofuranamine and 0.100 gm (0.56 mMol) of isonicotinoyl chloride hydrochloride, 0.036 gm (36%) of the title compound were recovered in two crops from toluene/hexane by the procedure described in Example 24.

Sources & evidence

ORD record
ord-2b6f36dba5ae4179ad24c8ba567e7c13
Source dataset
uspto-grants-1998_12
Patent number
US05846995

Reaction notes

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