反应详情

A mixture of tosylmethyl isocyanide (5.86 g, 30 mmol), benzaldehyde (3.18 g, 30 mmol) and K2CO3 (6.22 g, 45 mmol) in 60 ml MeOH was refluxed for 2 hr and concentrated. 250 ml EtOAc was added and the mixture was washed with H2O, brine, dried and concentrated. The residue was chromatographed on silica gel using 15:1 hexane/EtOAc to afford the title compound of this step (2.5 g, 57%) as a white solid.

1. temperaturewas refluxed for 2 hr
2. concentrationconcentrated
3. addition250 ml EtOAc was added
4. washthe mixture was washed with H2O, brine
5. customdried
6. concentrationconcentrated
7. customThe residue was chromatographed on silica gel using 15:1 hexane/EtOAc