1,1-Dimethylethyl 3,3-dimethyl-2-oxo-1-piperidinecarboxylate → 3,3-Dimethylpiperidin-2-one

HRID 1457220Notes

Reaction equation

HRID 1457220 reaction equation
[CH3:1][C:2]1([CH3:16])[CH2:7][CH2:6][CH2:5][N:4](C(OC(C)(C)C)=O)[C:3]1=[O:15]>CO.Cl.CCOCC>[CH3:1][C:2]1([CH3:16])[CH2:7][CH2:6][CH2:5][NH:4][C:3]1=[O:15]

Participants

5

Reactant 1

HCID 572676081,1-Dimethylethyl 3,3-dimethyl-2-oxo-1-piperidinecarboxylate

Product 1

HCID 112404853,3-Dimethylpiperidin-2-one

Reagents, catalysts & solvents 3

HCID 313Hydrochloric AcidSolventHCID 887MethanolSolventHCID 3283Diethyl EtherSolvent

Procedure

The title compound of Step (B) (440 mg, 1.94 mmol) in 4 ml MeOH and 15 ml 1N HCl in Et2O was stirred at room temperature overnight. The solvent was evaporated and dried in vacuo to provide the title compound of this step as a light yellow solid which was relatively pure and was used in the next step without further purification.

Workup

  1. customThe solvent was evaporated
  2. customdried in vacuo

Sources & evidence

ORD record
ord-c0761b5ec2644a81975de9f8880552eb
Source dataset
uspto-grants-1998_12
Patent number
US05846990

Reaction notes

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