Triethylamine → HCID 22104000, compound

HRID 1457227Notes

Reaction equation

HRID 1457227 reaction equation
C1(N=C=NC2CCCCC2)CCCCC1.[C:16]([NH:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][C:30]([OH:32])=O)(=[O:23])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1.Cl.[CH2:34]([O:36][C:37](=[O:40])[CH2:38][NH2:39])[CH3:35].C(N(CC)CC)C.ON1C2C=CC=CC=2N=N1>O1CCCC1>[CH2:34]([O:36][C:37](=[O:40])[CH2:38][NH:39][C:30](=[O:32])[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25][NH:24][C:16](=[O:23])[C:17]1[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1)[CH3:35]

Participants

7

Reactant 5

HCID 8471TriethylamineHCID 10868DicyclohexylcarbodiimideHCID 703886-Benzamidohexanoic acidHCID 757711-HydroxybenzotriazoleHCID 2723640Glycine ethyl ester, hydrochloride

Product 1

HCID 22104000HCID 22104000, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Conditions

Temperature
0 °C

Procedure

A solution of dicyclohexylcarbodiimide (112 mmoles) in anhydrous tetrahydrofuran (44 ml) was gradually added to a suspension of N-benzoyl-6-aminohexanoic acid (93.5 mmoles), prepared as described in example 1, glycine ethyl ester hydrochloride (112 mmoles), triethylamine (112 mmoles) and anhydrous 1-hydroxybenzotriazole (112 mmoles) in tetrahydrofuran (330 ml), kept under stirring at 0° C. The reaction mixture was brought at room temperature and kept under stirring for 16 hours.

Workup

  1. customprepared
  2. customwas brought at room temperature
  3. stirringunder stirring for 16 hours

Sources & evidence

ORD record
ord-72d1a84a6c4e45029ce97a96436ac908
Source dataset
uspto-grants-1998_12
Patent number
US05847092

Reaction notes

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