Iodine → HCID 131720978, compound

HRID 1457518Notes

Reaction equation

HRID 1457518 reaction equation
II.C1C=C2C(C(O)(O)C(=O)C2=CC=1)=O.[NH2:16][C:17]([NH2:26])([NH2:25])[CH2:18][CH2:19][CH2:20][CH2:21][C:22]([OH:24])=[O:23].[OH:27][C:28]([CH2:30][CH2:31][CH2:32][CH2:33][C@H:34]1[C@@H:42]2[C@@H:37]([NH:38][C:39]([NH:41]2)=[O:40])[CH2:36][S:35]1)=[O:29]>C(Cl)(Cl)Cl.CO>[NH2:26][C:17]([NH2:16])([NH2:25])[CH2:18][CH2:19][CH2:20][CH2:21][C:22]([OH:24])=[O:23].[OH:29][C:28]([CH2:30][CH2:31][CH2:32][CH2:33][C@H:34]1[C@@H:42]2[C@@H:37]([NH:38][C:39]([NH:41]2)=[O:40])[CH2:36][S:35]1)=[O:27]

Participants

6

Reactant 4

HCID 807IodineHCID 10236NinhydrinHCID 171548BiotinHCID 131720979HCID 131720979, compound

Product 1

HCID 131720978HCID 131720978, compound

Reagents, catalysts & solvents 1

HCID 21584188Chloroform methanolSolvent

Procedure

Silica gel thin layer chromatography, in 8/2 chloroform/methanol and visualized with iodine and ninhydrin spray, was used at various stages of the synthesis to show disappearance of the starting amine and appearance of the biotin acid derivative.

Workup

  1. customwas used at various stages of the synthesis

Sources & evidence

ORD record
ord-4dd653f2b4774a02a9452b2a4903294a
Source dataset
uspto-grants-1998_12
Patent number
US05849599

Reaction notes

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