反应详情

To the suspension of 12-aminododecanoic acid (2.15 g; 10 mmol) in 2,2-dimethoxypropane (100 ml) was added 36% aqueous HCl (10 ml) and the mixture was treated in an ultrasonic bath until all solid material was dissolved. The mixture was then left to stand overnight, concentrated to dryness, dissolved in 40 ml of methanol and precipitated with approximately 500 ml of dry ether to give 2.4 g of 1 (90.5% yield).

1. additionthe mixture was treated in an ultrasonic bath until all solid material
2. dissolutionwas dissolved
3. waitThe mixture was then left
4. concentrationconcentrated to dryness
5. dissolutiondissolved in 40 ml of methanol
6. customprecipitated with approximately 500 ml of dry ether