Triethylamine → HCID 22099546, compound

HRID 1457702Notes

Reaction equation

HRID 1457702 reaction equation
[N:1]1[C:6]2[NH:7][C:8]3[CH:15]=[CH:14][CH:13]=[CH:12][C:9]=3[CH2:10][NH:11][C:5]=2[CH:4]=[CH:3][CH:2]=1.[F:16][C:17]1[CH:18]=[CH:19][C:20]([CH3:35])=[C:21]([CH:34]=1)[C:22]([NH:24][C:25]1[N:30]=[CH:29][C:28]([C:31](Cl)=[O:32])=[CH:27][CH:26]=1)=[O:23].C(N(CC)CC)C>ClCCl>[N:1]1[C:6]2[NH:7][C:8]3[CH:15]=[CH:14][CH:13]=[CH:12][C:9]=3[CH2:10][N:11]([C:31]([C:28]3[CH:27]=[CH:26][C:25]([NH:24][C:22](=[O:23])[C:21]4[CH:34]=[C:17]([F:16])[CH:18]=[CH:19][C:20]=4[CH3:35])=[N:30][CH:29]=3)=[O:32])[C:5]=2[CH:4]=[CH:3][CH:2]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 155082506-(5-Fluoro-2-methylbenzoyl)aminopyridine-3-carbonyl chlorideHCID 22099611HCID 22099611, compound

Product 1

HCID 22099546HCID 22099546, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

As described for Example 1, 6,11-dihydro-5H-pyrido[2,3-b][1,4]benzodiazepine (2 mmol) is reacted with 6-[(5-fluoro-2-methylbenzoyl)amino]pyridine-3-carbonyl chloride (2.1 mmol) in the presence of triethylamine (4 mmol) in dichloromethane to give the product as a solid, m.p. 102° C.-104° C.

Sources & evidence

ORD record
ord-22a951f5b7e443d7a678962dbb01a0dd
Source dataset
uspto-grants-1998_12
Patent number
US05849735

Reaction notes

Loading…