反应详情

1.5 g of 3-acetyl-4-fluoro-benzoic acid n-butylester, 0.6 g of 3-hydroxypyridine and 4.1 g of Cs2CO3 are stirred in 20 ml of tetramethylurea for 2 h at 110° C. After cooling to RT the mixture is poured into 200 ml EE and the mixture is washed 3 times with 100 ml brine. Drying takes place over Na2SO4 and the solvent is distilled off in vacuo. Chromatography over silica gel with MTB furnishes 1.3 g of a pale yellow oil. Rf (MTB)=0.30 MS (DCI): 314 (M+H)+

1. additionis poured into 200 ml EE
2. washthe mixture is washed 3 times with 100 ml brine
3. customDrying
4. distillationthe solvent is distilled off in vacuo