Dimethylformamide → HCID 22101154, compound

HRID 1457924Notes

Reaction equation

HRID 1457924 reaction equation
[C:1]1([NH:7][C:8]([NH:10][C:11]2[C:15]([C:16]([O:18]CC3C=CC=CC=3)=[O:17])=[CH:14][N:13]([CH2:26][C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)[N:12]=2)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.CN(C=O)C>[Pd].CO>[C:1]1([NH:7][C:8]([NH:10][C:11]2[C:15]([C:16]([OH:18])=[O:17])=[CH:14][N:13]([CH2:26][C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)[N:12]=2)=[O:9])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

5

Reactant 2

HCID 6228DimethylformamideHCID 22101145HCID 22101145, compound

Product 1

HCID 22101154HCID 22101154, compoundYield 86.2%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A mixture of the compound of Example 4 (300 mg, 0.7 mmol), DMF (5 ml), methanol (40 ml), and 5% Pd/C (30 mg) was stirred for 24 h under hydrogen. After filtration of the reaction mixture, the filtrate was evaporated under reduced pressure to give the title compound (203 mg, yield 86%).

Workup

  1. filtrationAfter filtration of the reaction mixture
  2. customthe filtrate was evaporated under reduced pressure

Sources & evidence

ORD record
ord-090e7da7844243d882e71cdc4d816db7
Source dataset
uspto-grants-1998_12
Patent number
US05849779

Reaction notes

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