Methyl iodide → HCID 22101417, compound

HRID 1457947Notes

Reaction equation

HRID 1457947 reaction equation
[Br:1][C:2]1[CH:10]=[C:9]([F:11])[C:8]([S:12]([CH3:15])(=[O:14])=[O:13])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].CI.[C:18](=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[Br:1][C:2]1[CH:10]=[C:9]([F:11])[C:8]([S:12]([CH3:15])(=[O:14])=[O:13])=[CH:7][C:3]=1[C:4]([O:6][CH3:18])=[O:5]

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 221013972-Bromo-4-fluoro-5-(methylsulfonyl)benzoic acid

Product 1

HCID 22101417HCID 22101417, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

5.8 g of 2-bromo-4-fluoro-5-methylsulphonylbenzoic acid are stirred, at room temperature for 12 h, in 20 ml of DMF together with 3.7 ml of methyl iodide and 8.3 g of potassium carbonate. The reaction mixture is then concentrated and 50 ml of water are added to it. The resulting precipitate is filtered off with suction and dried. Methyl 2-bromo-4-fluoro-5-methylsulphonylbenzoate is obtained, m.p. 126°.

Workup

  1. concentrationThe reaction mixture is then concentrated
  2. addition50 ml of water are added to it
  3. filtrationThe resulting precipitate is filtered off with suction
  4. customdried

Sources & evidence

ORD record
ord-e7e81265df5449dca25d05449d7eb82e
Source dataset
uspto-grants-1998_12
Patent number
US05849796

Reaction notes

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