Dimethyl Sulfoxide → 3-[(N-acetylprolyl)alanylprolylamino]-2,2-dihydroxybutanoic acid, methyl ester
Reaction equation
C(Cl)(=O)C(Cl)=[O:3].CS(C)=O.[C:11]([N:14]1[CH2:41][CH2:40][CH2:39][C@H:15]1[C:16]([NH:18][C@H:19]([C:21]([N:23]1[CH2:38][CH2:37][CH2:36][C@H:24]1[C:25]([NH:27][CH:28]([CH3:35])[CH:29]([OH:34])[C:30]([O:32][CH3:33])=[O:31])=[O:26])=[O:22])[CH3:20])=[O:17])(=[O:13])[CH3:12].C(N(CC)CC)C>C(Cl)Cl>[C:11]([N:14]1[CH2:41][CH2:40][CH2:39][C@H:15]1[C:16]([NH:18][C@H:19]([C:21]([N:23]1[CH2:38][CH2:37][CH2:36][C@H:24]1[C:25]([NH:27][CH:28]([CH3:35])[C:29]([OH:3])([OH:34])[C:30]([O:32][CH3:33])=[O:31])=[O:26])=[O:22])[CH3:20])=[O:17])(=[O:13])[CH3:12]Participants
Reactant 4
Product 1
Reagents, catalysts & solvents 1
Procedure
To a stirred solution of oxalyl chloride (0.12 ml, 1.43 mmol) in methylene chloride (1.5 ml) under an argon atmosphere and cooled in a dry ice-acetone bath was added dropwise a solution of dimethylsulfoxide (0.20 ml, 2.86 mmol) in methylene chloride (1.5 ml). After 5 minutes, a solution of the product of example 59 (0.32 g, 0.72 mmol) in methylene chloride (1.5 ml) was added and the reaction mixture stirred for 25 minutes. Triethylamine (0.50 ml, 3.58 mmol) was added and the reaction mixture warmed to room temperature. The reaction mixture was placed directly onto a silica gel column and eluted with methylene chloride-methanol. Evaporation of the appropriate fractions on a rotary evaporator, addition of water (3 ml) to the residue and evaporation gave the above-named product.
Workup
- washeluted with methylene chloride-methanol
- customEvaporation of the appropriate fractions
- customon a rotary evaporator, addition of water (3 ml)
- customto the residue and evaporation
- customgave the above-named product
Sources & evidence
- ORD record
- ord-ba306ac48275459f895f848d9bf564d2
- Source dataset
- uspto-grants-1998_12
- Patent number
- US05849866
Reaction notes
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