Methyl iodide → HCID 22101837, compound

HRID 1458220Notes

Reaction equation

HRID 1458220 reaction equation
[H-].[Na+].[CH3:3][C:4]1[N:5]=[CH:6][S:7][C:8]=1[CH:9]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[OH:10].[CH3:17]I>CN(C)C=O>[CH3:3][C:4]1[N:5]=[CH:6][S:7][C:8]=1[CH:9]([O:10][CH3:17])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 22101805HCID 22101805, compound

Product 1

HCID 22101837HCID 22101837, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Sodium hydride (80% dispersion in mineral oil, 80 mg) was added to a stirred solution of 1-(4-methyl-5-thiazolyl)-1-phenyl-methanol (500 mg) in dry N,N-dimethylformamide (10 ml) at 0° C. After 10 minutes, methyl iodide (0.15 ml) was added. The mixture was allowed to warm to room temperature and after a further 30 minutes the mixture was evaporated to dryness. The residue was purified by flash chromatography to give the title compound.

Workup

  1. customwas evaporated to dryness
  2. customThe residue was purified by flash chromatography

Sources & evidence

ORD record
ord-31bf39e19cea479e9dbc7f5890d43cee
Source dataset
uspto-grants-1998_12
Patent number
US05849921

Reaction notes

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