反应详情

In a mixed solution of 2.0 g of succinic anhydride and 50 ml of 1,2-dichloroethane, 6.7 g of aluminum chloride were added, followed by stirring at room temperature for 40 minutes. To the resulting mixture, 20 ml of 2 -fluorotoluene were added dropwise at room temperature and they were stirred for 20 minutes, followed by further stirring for 20 minutes at an external temperature of 50° C. The reaction mixture was cooled and then poured into ice water to which 5% hydrochloric acid had been added. The resulting mixture was extracted with chloroform. The chloroform layer was washed with water and dried over anhydrous magnesium sulfate. The solvent was then evaporated. The residue so obtained was recrystallized from chloroform, whereby 3.2 g of the title compound was obtained.

1. stirringthey were stirred for 20 minutes
2. stirringby further stirring for 20 minutes at an external temperature of 50° C
3. temperatureThe reaction mixture was cooled
4. additionhad been added
5. extractionThe resulting mixture was extracted with chloroform
6. washThe chloroform layer was washed with water
7. dry with materialdried over anhydrous magnesium sulfate
8. customThe solvent was then evaporated
9. customThe residue so obtained
10. customwas recrystallized from chloroform