Trimethylamine → HCID 14239709, compound

HRID 1458582Notes

Reaction equation

HRID 1458582 reaction equation
[OH:1][CH2:2][C:3]1[CH:7]=[CH:6][NH:5][N:4]=1.[C:8](Cl)([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.CN(C)C>>[OH:1][CH2:2][C:3]1[CH:7]=[CH:6][N:5]([C:8]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)([C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=2)[C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=2)[N:4]=1

Participants

4

Reactant 3

HCID 1146TrimethylamineHCID 6456Trityl chlorideHCID 178519763HCID 178519763, compound

Product 1

HCID 14239709HCID 14239709, compoundYield 60%

Procedure

This compound was prepared from 3-(hydroxymethyl)-1 H-pyrazole, [J. Am. Chem. Soc, 71, 3996, (1949)], trityl chloride and trimethylamine using the method of Preparation 18, above. The crude product was purified by flash chromatography (gradient elution with hexane/ethyl acetate) to give a white solid (1.428 g, 60%).

Workup

  1. customthe method of Preparation 18
  2. customThe crude product was purified by flash chromatography (gradient elution with hexane/ethyl acetate)

Sources & evidence

ORD record
ord-b087be63e31642a5a1e6979ccf0645d6
Source dataset
uspto-grants-1998_12
Patent number
US05852016

Reaction notes

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