HCID 22096808, compound → HCID 9904129, compound

HRID 1458701Notes

Reaction equation

HRID 1458701 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:10]=[CH:11][C:12]=1[N:13]([CH2:17][CH2:18][Cl:19])[CH2:14][CH2:15][Cl:16])[C:6]([O:8]C)=[O:7]>Cl>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:10]=[CH:11][C:12]=1[N:13]([CH2:14][CH2:15][Cl:16])[CH2:17][CH2:18][Cl:19])[C:6]([OH:8])=[O:7]

Participants

3

Reactant 1

HCID 22096808HCID 22096808, compound

Product 1

HCID 9904129HCID 9904129, compoundYield 74%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

Methyl 3-methoxy-4-[bis(2-chloroethyl)amino]benzoate (1.0 g; 3.3 mmol) was added to 20 ml of concentrated hydrochloric acid, followed by stirring for 30 minutes under heating and reflux. The solvent was distilled out under reduced pressure, whereby 707 mg of white powder were obtained (yield: 74%).

Workup

  1. temperatureunder heating
  2. temperaturereflux
  3. distillationThe solvent was distilled out under reduced pressure

Sources & evidence

ORD record
ord-6637bddd2977420385490755b5154a81
Source dataset
uspto-grants-1998_12
Patent number
US05852011

Reaction notes

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