反应详情

温度

140 °C

In 30 ml of DMSO, 4.0 g (25.8 mmol) of 2-fluoro-5-nitrotoluene and 7.0 g (67 mmol) of diethanolamine were dissolved. The resultant solution was stirred under heat at 140° C. for 6.5 hours, followed by extraction with ethyl acetate. The solvent was distilled out under reduced pressure. The residue so obtained was washed with ethyl acetate, whereby 5.2 g of the title compound were obtained as yellow powder (yield: 84%).

1. extractionfollowed by extraction with ethyl acetate
2. distillationThe solvent was distilled out under reduced pressure
3. customThe residue so obtained
4. washwas washed with ethyl acetate