Diethanolamine → HCID 22096786, compound

HRID 1458726Notes

Reaction equation

HRID 1458726 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7](F)=[CH:6][C:5]=1[CH3:11])([O-:3])=[O:2].[NH:12]([CH2:16][CH2:17][OH:18])[CH2:13][CH2:14][OH:15]>CS(C)=O>[CH3:11][C:5]1[CH:6]=[C:7]([N:12]([CH2:16][CH2:17][OH:18])[CH2:13][CH2:14][OH:15])[CH:8]=[CH:9][C:4]=1[N+:1]([O-:3])=[O:2]

Participants

4

Reactant 2

HCID 8113DiethanolamineHCID 949565-Fluoro-2-nitrotoluene

Product 1

HCID 22096786HCID 22096786, compoundYield 65.2%

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Conditions

Temperature
140 °C

Procedure

In 8 ml of DMSO, 5.0 g (64.5 mmol) of 2-nitro-5-fluorotoluene and 8.2 g (78 mmol) of diethanolamine were dissolved. The resultant solution was stirred under heat at 140° C. for 7 hours, followed by extraction with ethyl acetate. After the solvent was distilled out under reduced pressure, the residue was washed with ethyl acetate, whereby 10.1 g of yellow powder were obtained (yield: 65%).

Workup

  1. extractionfollowed by extraction with ethyl acetate
  2. distillationAfter the solvent was distilled out under reduced pressure
  3. washthe residue was washed with ethyl acetate

Sources & evidence

ORD record
ord-69b9bd8b1e7b43a4b6329d385353c35c
Source dataset
uspto-grants-1998_12
Patent number
US05852011

Reaction notes

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