反应详情

A mixture of N-(1-ethylpyrazol-5-yl)-4-methoxyanthranilic acid (13.3 g, 0.051 mol) and POCl3 (125 ml) is refluxed for 3 hours, then is allowed to sit overnight. The volume of POCl3 is reduced, then ice water, followed by NH4OH are added. A precipitate forms which is collected by filtration and dried in a vacuum oven at 50° C. to afford 11.51 g (87%) of 1-ethyl-4-chloro-7-methoxy-1H-pyrazolo[3,4-b]quinoline, m.p. 95°-98° C.

1. temperatureis refluxed for 3 hours
2. additionare added
3. filtrationA precipitate forms which is collected by filtration
4. customdried in a vacuum oven at 50° C.