Lithium Hydroxide → HCID 22097088, compound

HRID 1458869Notes

Reaction equation

HRID 1458869 reaction equation
C([O:3][C:4]([CH2:6][N:7]1[C:16]2[C:11](=[CH:12][C:13]([N+:22]([O-:24])=[O:23])=[C:14]([N:17]3[CH:21]=[CH:20][CH:19]=[CH:18]3)[CH:15]=2)[NH:10][C:9](=[O:25])[C:8]1=[O:26])=[O:5])C.[OH-].[Li+]>O1CCCC1.O>[C:4]([CH2:6][N:7]1[C:16]2[C:11](=[CH:12][C:13]([N+:22]([O-:24])=[O:23])=[C:14]([N:17]3[CH:21]=[CH:20][CH:19]=[CH:18]3)[CH:15]=2)[NH:10][C:9](=[O:25])[C:8]1=[O:26])([OH:5])=[O:3]

Participants

5

Reactant 2

HCID 3939Lithium HydroxideHCID 22097062HCID 22097062, compound

Product 1

HCID 22097088HCID 22097088, compoundYield 77.9%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

24.5 g (68 mmol) of 1-(ethoxycarbonylmethyl)-6-nitro-7-(1-pyrrolyl)-2,3(1H,4H)-quinoxalinedione (Example 52) were dissolved in 500 ml of tetrahydrofuran, and a solution of 6.6 g (270 mmol) of lithium hydroxide in 100 ml of water was added. The mixture was stirred at room temperature for 16 h and then the tetrahydrofuran was removed under reduced pressure, and the aqueous phase was filtered. The filtrate was acidified with 1M hydrochloric acid, and,the precipitate was filtered off with suction to yield 17.5 g (77%) of the product.

Workup

  1. customthe tetrahydrofuran was removed under reduced pressure
  2. filtrationthe aqueous phase was filtered
  3. filtrationand,the precipitate was filtered off with suction

Sources & evidence

ORD record
ord-f2fc0ca2169043ad9fdda96f9dc88d64
Source dataset
uspto-grants-1998_12
Patent number
US05852017

Reaction notes

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