1-Naphthaldehyde → HCID 22876507, compound

HRID 1459055Notes

Reaction equation

HRID 1459055 reaction equation
[NH:1]1[CH2:7][CH2:6][CH2:5][C@H:2]1[CH2:3][OH:4].[C:8]1([CH:18]=O)[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH:11]=[CH:10][CH:9]=1>>[C:8]1([CH2:18][N:1]2[CH2:7][CH2:6][CH2:5][C@H:2]2[CH2:3][OH:4])[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH:11]=[CH:10][CH:9]=1

Participants

3

Reactant 2

HCID 61951-NaphthaldehydeHCID 640091L-Prolinol

Product 1

HCID 22876507HCID 22876507, compound

Procedure

Using (S)-prolinol ((S)-VIII-1) and α-naphthoaldehyde as the starting materials, a similar operation was carried out to obtain (S)-N-(α-naphthyl)methyl-2-pyrrolidine methanol ((S)-II-2). ##STR316## [α] D20 65.6° (C=0.16, CH3OH) IR spectrum (NaCl) νmax cm-1 : 3400, 3040, 2950, 2870, 1600, 1500, 1460, 1350, 1170, 1040, 800, 790, 780 1H-NMR (CDCl3) δ ppm :7.25-8.30 (7 H, m, aromatic-H), 2.60-4.55 (7 H, m, other -H), 2.35 (1 H, br, OH), 1.65-2.01 (4 H, m, C--CH2CH2 --C)

Sources & evidence

ORD record
ord-4188f52916fa4f88b0e50380616c54ac
Source dataset
uspto-grants-1998_12
Patent number
US05852221

Reaction notes

Loading…