N-methyl-2-pyrrolidone → HCID 53723146, compound

HRID 1459082Notes

Reaction equation

HRID 1459082 reaction equation
FC1C=CC(C#N)=CC=1.[C:10]([C:12]1[CH:17]=[CH:16][C:15]([N:18]2[CH2:22][CH2:21][N:20]([C:23]3[CH:28]=[CH:27][C:26]([CH2:29][CH2:30][C:31]([O:33][CH3:34])=[O:32])=[CH:25][CH:24]=3)S2(=O)=O)=[CH:14][CH:13]=1)#[N:11].[H-].[Na+].CN1CCC[C:41]1=[O:45]>[Cu]>[C:10]([C:12]1[CH:17]=[CH:16][C:15]([N:18]2[CH2:22][CH2:21][N:20]([CH:23]3[CH2:28][CH2:27][CH:26]([CH2:29][CH2:30][C:31]([O:33][CH3:34])=[O:32])[CH2:25][CH2:24]3)[C:41]2=[O:45])=[CH:14][CH:13]=1)#[N:11]

Participants

5

Reactant 3

HCID 13387N-methyl-2-pyrrolidoneHCID 24758Sodium hydrideHCID 67850672HCID 67850672, compound

Product 1

HCID 53723146HCID 53723146, compound

Reagents, catalysts & solvents 1

HCID 23978CopperCatalyst

Procedure

2-(4-cyano-phenyl)-5-[4-(2-methoxycarbonyl-ethyl)-phenyl]-3,4-dihydro-2H,5H-1,2,5-thiadiazole-1,1-dioxide 4-Fluoro-benzonitrile and sodium hydride in N-methylpyrrolidone were used without copper salts.

Sources & evidence

ORD record
ord-acf289c926054cb980d7e2b23552e640
Source dataset
uspto-grants-1998_12
Patent number
US05852192

Reaction notes

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