HCID 15278740, compound → HCID 15278797, compound

HRID 1459288Notes

Reaction equation

HRID 1459288 reaction equation
C([NH:5][S:6]([C:9]1[CH:14]=[C:13]([NH:15][CH:16]=[O:17])[CH:12]=[CH:11][C:10]=1[S:18]([CH2:21][CH3:22])(=[O:20])=[O:19])(=[O:8])=[O:7])(C)(C)C>FC(F)(F)C(O)=O>[CH2:21]([S:18]([C:10]1[CH:11]=[CH:12][C:13]([NH:15][CH:16]=[O:17])=[CH:14][C:9]=1[S:6]([NH2:5])(=[O:7])=[O:8])(=[O:20])=[O:19])[CH3:22]

Participants

3

Reactant 1

HCID 15278740HCID 15278740, compound

Product 1

HCID 15278797HCID 15278797, compoundYield 65.6%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

3.0 g of N-tert-butyl-2-ethylsulfonyl-5-formylaminobenzenesulfonamide are stirred in 20 ml of trifluoroacetic acid. When the reaction has ended, the trifluoroacetic acid is distilled off. The residue is stirred with a little ethyl acetate. After the solid has been separated off and dried, 1.65 g of the desired sulfonamide are obtained; melting point: 186° to 189° C.

Workup

  1. distillationthe trifluoroacetic acid is distilled off
  2. customAfter the solid has been separated off
  3. customdried

Sources & evidence

ORD record
ord-c1c3a102ce21427a90e9c2a25855d8a4
Source dataset
uspto-grants-1998_12
Patent number
US05854179

Reaction notes

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