Ethanol → (4-amino-3-methoxy-phenyl)[10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-10-yl]methanone

HRID 1459584Notes

Reaction equation

HRID 1459584 reaction equation
[N+:1]([C:4]1[CH:25]=[CH:24][C:7]([C:8]([N:10]2[C:16]3[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=3[CH2:14][N:13]3[CH:21]=[CH:22][CH:23]=[C:12]3[CH2:11]2)=[O:9])=[CH:6][C:5]=1[O:26][CH3:27])([O-])=O.O.O.Cl[Sn]Cl.C(O)C.O1CCCC1>C(Cl)Cl>[NH2:1][C:4]1[CH:25]=[CH:24][C:7]([C:8]([N:10]2[C:16]3[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=3[CH2:14][N:13]3[CH:21]=[CH:22][CH:23]=[C:12]3[CH2:11]2)=[O:9])=[CH:6][C:5]=1[O:26][CH3:27]

Participants

6

Reactant 4

HCID 702EthanolHCID 8028TetrahydrofuranHCID 61436Stannous chloride dihydrateHCID 1071374010,11-dihydro-10-(4-nitro-3-methoxybenzoyl)-5H-pyrrolo[2,1-c][1,4]benzodiazepine

Product 1

HCID 10806563(4-amino-3-methoxy-phenyl)[10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-10-yl]methanone

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
50 °C

Procedure

A mixture of 0.91 g of 10,11-dihydro-10-(4-nitro-3-methoxybenzoyl)-5H-pyrrolo[2,1-c][1,4]benzodiazepine, 4.51 g of SnCl2.2H2O, 6 ml of ethyl alcohol, 6 ml of tetrahydrofuran and 16 ml of methylene chloride is stirred at 50° C. for 2 hours. The solvents are evaporated in vacuo and the residue dissolved in 80 ml of ethyl acetate. The solution is treated with 50 ml of 1N NaOH with stirring for 30 minutes. The resulting suspension is filtered through diatomaceous earth. The pad is washed with ethyl acetate (3×15 ml). The combined ethyl acetate solutions are washed with brine, dried (Na2SO4), filtered through hydrous magnesium silicate and evaporated in vacuo to 0.99 g of residue which is stirred with ether-hexanes to give 0.90 g of cream colored solid. MS(CI):334(M+H).

Workup

  1. customThe solvents are evaporated in vacuo
  2. dissolutionthe residue dissolved in 80 ml of ethyl acetate
  3. additionThe solution is treated with 50 ml of 1N NaOH
  4. stirringwith stirring for 30 minutes
  5. filtrationThe resulting suspension is filtered through diatomaceous earth
  6. washThe pad is washed with ethyl acetate (3×15 ml)
  7. washThe combined ethyl acetate solutions are washed with brine
  8. dry with materialdried (Na2SO4)
  9. filtrationfiltered through hydrous magnesium silicate
  10. customevaporated in vacuo to 0.99 g of residue which
  11. stirringis stirred with ether-hexanes
  12. customto give 0.90 g of cream

Sources & evidence

ORD record
ord-1fb7418cdf2a4bbc9dd5cc5a2b17cd66
Source dataset
uspto-grants-1998_12
Patent number
US05854237

Reaction notes

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