N-Methylbenzylamine → HCID 9886181, compound

HRID 1460064Notes

Reaction equation

HRID 1460064 reaction equation
Cl[C:2]1[C:7]([N+:8]([O-])=O)=[C:6](Cl)[N:5]=[C:4]([S:12][CH3:13])[N:3]=1.[CH2:14]([NH:21][CH3:22])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1.[CH2:23]([C:25]1[NH:26][CH:27]=[CH:28][N:29]=1)[CH3:24].[Sn](Cl)Cl.[C:33](N1C=CN=C1)(N1C=CN=C1)=[O:34]>>[CH2:23]([C:25]1[N:29]2[C:28]([C:33](=[O:34])[NH:8][C:7]3[C:2]([N:21]([CH3:22])[CH2:14][C:15]4[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=4)=[N:3][C:4]([S:12][CH3:13])=[N:5][C:6]=32)=[CH:27][N:26]=1)[CH3:24]

Participants

6

Reactant 5

HCID 7669N-MethylbenzylamineHCID 24479Stannous ChlorideHCID 661302-EthylimidazoleHCID 682631,1'-CarbonyldiimidazoleHCID 113454584,6-Dichloro-2-(methylthio)-5-nitropyrimidine

Product 1

HCID 9886181HCID 9886181, compound

Procedure

Prepared by treatment of 4,6dichloro-5-nitro-2-(methylthio)pyrimidine with N-benzyl methylamine, followed by reaction with 2-ethylimidazole, reduction with tin (II) chloride, and cyclization with carbonyldiimidazole.

Sources & evidence

ORD record
ord-97454721891849d984da51de56a8a3c7
Source dataset
uspto-grants-1998_12
Patent number
US05854419

Reaction notes

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