3-Amino-1,2-propanediol → HCID 19358861, compound

HRID 1460065Notes

Reaction equation

HRID 1460065 reaction equation
[CH2:1]([C:3]1[C:12]2[NH:11][C:10](=[O:13])[C:9]3=[C:14]([CH3:19])[N:15]=[C:16]([CH2:17][CH3:18])[N:8]3[C:7]=2[N:6]=[C:5](S(C)(=O)=O)[N:4]=1)[CH3:2].[NH2:24][CH2:25][CH:26]([OH:29])[CH2:27][OH:28]>CN1CCCC1=O>[OH:29][CH:26]([CH2:27][OH:28])[CH2:25][NH:24][C:5]1[N:4]=[C:3]([CH2:1][CH3:2])[C:12]2[NH:11][C:10](=[O:13])[C:9]3=[C:14]([CH3:19])[N:15]=[C:16]([CH2:17][CH3:18])[N:8]3[C:7]=2[N:6]=1

Participants

4

Reactant 2

HCID 735613-Amino-1,2-propanediolHCID 19358842HCID 19358842, compound

Product 1

HCID 19358861HCID 19358861, compound

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

Prepared by the treatment of the product of Example 41b with 10 eq. of 3-amino-1,2-propanediol in N-methylpyrrolidinone at 100° C. for 18 h. The mixture was poured on water to precipitate the product. The solids were filtered, washed with water, and then acetonitrile, to provide the title compound.

Workup

  1. additionThe mixture was poured on water
  2. customto precipitate the product
  3. filtrationThe solids were filtered
  4. washwashed with water

Sources & evidence

ORD record
ord-e07771e234604f11833763cc05eabd0d
Source dataset
uspto-grants-1998_12
Patent number
US05854419

Reaction notes

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