反应详情

A mixture of 31.5 g (0.14 mol) of 2-(acetyloxy)-1-(4-hydroxy-3-methoxyphenyl)ethanone, 44.1 g (0.28 mole) of 1-bromo-3-chloropropane and 58 g (0.42 mole) of anhydrous potassium carbonate in 1 liter of acetone was heated at reflux for 16 hr. The mixture was cooled, filtered, and the filtrate concentrated to give a solid residue. The solid was triturated with petroleum ether (30°-60° C.), collected by filtration and dried to yield 38.7 g (92%) of title compound as a pale-yellow solid. An analytical sample, mp 93°-96° C., was prepared from 2-propanol.

1. temperaturewas heated
2. temperatureat reflux for 16 hr
3. temperatureThe mixture was cooled
4. filtrationfiltered
5. concentrationthe filtrate concentrated
6. customto give a solid residue
7. customThe solid was triturated with petroleum ether (30°-60° C.)
8. filtrationcollected by filtration
9. customdried