Benzenesulfonyl chloride → Ethyl 1-(phenylsulfonyl)piperidine-4-carboxylate

HRID 1460235Notes

Reaction equation

HRID 1460235 reaction equation
[NH:1]1[CH2:11][CH2:10][CH:4]([C:5]([O:7][CH2:8][CH3:9])=[O:6])[CH2:3][CH2:2]1.[C:12]1([S:18](Cl)(=[O:20])=[O:19])[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>>[CH2:8]([O:7][C:5]([CH:4]1[CH2:3][CH2:2][N:1]([S:18]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)(=[O:20])=[O:19])[CH2:11][CH2:10]1)=[O:6])[CH3:9]

Participants

3

Reactant 2

HCID 7369Benzenesulfonyl chlorideHCID 70770Ethyl 4-piperidinecarboxylate

Product 1

HCID 257103Ethyl 1-(phenylsulfonyl)piperidine-4-carboxylateYield 78%

Procedure

In another preparation, 100 g (0.634 mole) of ethyl isonipecotate and 130.4 g (0.74 mole) of benzenesulfonyl chloride were reacted by the above procedure for 4.5 hr to give the title product in 78% yield.

Workup

  1. customwere reacted by the above procedure for 4.5 hr

Sources & evidence

ORD record
ord-b9cd770a4fc644069907a552deaf4752
Source dataset
uspto-grants-1991_12
Patent number
US05070087

Reaction notes

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