Hydrochloric Acid → HCID 19801133, compound

HRID 1460581Notes

Reaction equation

HRID 1460581 reaction equation
[ClH:1].[CH3:2][CH:3]1[CH2:16][CH:15]2[C:10]([NH2:17])([CH2:11][CH:12]=[CH:13][CH2:14]2)[C:9]2[C:4]1=[CH:5][CH:6]=[CH:7][CH:8]=2.[H-].[Al+3].[Li+].[H-].[H-].[H-].Cl.[CH3:25]COCC>>[ClH:1].[CH3:25][NH:17][C:10]12[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[CH:3]([CH3:2])[CH2:16][CH:15]1[CH2:14][CH:13]=[CH:12][CH2:11]2

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 3283Diethyl Ether2×HCID 19107050HCID 19107050, compoundHCID 21226445Aluminium lithium hydride

Product 1

HCID 19801133HCID 19801133, compoundYield 81%

Procedure

A solution of the compound from Example 36 (0.65 g, 2.4 mmol) was reduced in a suspension of lithium aluminum hydride in ether as described in Example 33. A solution of the free amine in diethyl ether was treated with isopropanolic HCl to give the title compound (0.51 g, 81%), mp 248°-249° c.

Sources & evidence

ORD record
ord-99f3d9a998064254a7fdfc57f87c13e8
Source dataset
uspto-grants-1991_12
Patent number
US05071853

Reaction notes

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