HCID 14724732, compound → HCID 14724734, compound

HRID 1460722Notes

Reaction equation

HRID 1460722 reaction equation
[NH:1]([C:53]([CH3:55])=[O:54])[C@@H:2]([C:14]([NH:16][C@@H:17]([C:25]([NH:27][C@@H:28]([C:36]([NH:38][C@H:39]([C:46]([O:48]C(C)(C)C)=[O:47])[CH2:40][O:41]C(C)(C)C)=[O:37])[CH2:29][C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)=[O:26])[CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)=[O:15])[CH2:3][C:4]1[CH:13]=[C:12]2[C:7]([CH:8]=[CH:9][CH:10]=[CH:11]2)=[CH:6][CH:5]=1>FC(F)(F)C(O)=O.SCCS>[NH:1]([C:53]([CH3:55])=[O:54])[C@@H:2]([C:14]([NH:16][C@@H:17]([C:25]([NH:27][C@@H:28]([C:36]([NH:38][C@H:39]([C:46]([OH:48])=[O:47])[CH2:40][OH:41])=[O:37])[CH2:29][C:30]1[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=1)=[O:26])[CH2:18][C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1)=[O:15])[CH2:3][C:4]1[CH:13]=[C:12]2[C:7]([CH:8]=[CH:9][CH:10]=[CH:11]2)=[CH:6][CH:5]=1

Participants

4

Reactant 1

HCID 14724732HCID 14724732, compound

Product 1

HCID 14724734HCID 14724734, compound

Reagents, catalysts & solvents 2

HCID 6422Trifluoroacetic acidSolventHCID 109021,2-EthanedithiolSolvent

Procedure

10 g of Ac-D-Nal(2)-D-Phe-D-Phe-Ser(tBu)-OtBu are dissolved in a mixture of 40 ml of 90% strength aqueous trifluoroacetic acid and 1.6 ml of 1,2-dimercaptoethane. The mixture is left to stand at room temperature for one hour and is concentrated. The residue is triturated with water and dried under high vacuum.

Workup

  1. waitThe mixture is left
  2. concentrationis concentrated
  3. customThe residue is triturated with water
  4. customdried under high vacuum

Sources & evidence

ORD record
ord-734f945b13494f32a8cd9a815c47aa00
Source dataset
uspto-grants-1991_12
Patent number
US05071836

Reaction notes

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