Potassium Carbonate → 1,4-Diazatricyclo[6.3.0.02,5]undecane

HRID 1460778Notes

Reaction equation

HRID 1460778 reaction equation
[N:1]12[CH2:11][CH2:10][CH2:9][CH:8]1[CH2:7][CH:6]1[CH:2]2[CH2:3][N:4](C(OCC)=O)[CH2:5]1.C(=O)([O-])[O-].[K+].[K+]>Cl>[N:1]12[CH2:11][CH2:10][CH2:9][CH:8]1[CH2:7][CH2:6][CH:5]1[CH:2]2[CH2:3][NH:4]1

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 53870311Ethyl 1,4-diazatricyclo[6.3.0.02,6]undecane-4-carboxylate

Product 1

HCID 543425181,4-Diazatricyclo[6.3.0.02,5]undecane

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

9 g (40 mmol) of ethyl 1,4-diazatricyclo -[6.3.0.02,6 ]undecane-4-carboxylate are heated under reflux overnight with 50 ml of concentrated hydrochloric acid. The mixture is rendered alkaline with potassium carbonate and extracted ten times using 50 ml of chloroform each time, the extracts are dried over potassium carbonate and concentrated, and the residue is distilled.

Workup

  1. extractionextracted ten times
  2. dry with materialthe extracts are dried over potassium carbonate
  3. concentrationconcentrated
  4. distillationthe residue is distilled

Sources & evidence

ORD record
ord-796f87fafc804f6eaadfa35bd14eb6be
Source dataset
uspto-grants-1991_12
Patent number
US05071999

Reaction notes

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