反应详情

500 mg (2.62 mmol) of p-toluenesulfonyl chloride was added to a mixture of 480 mg (2.6 mmol) of (+)-3-trifluoromethyl-1-heptanol and 790 mg (10 mmol) of pyridine, and the resultant mixture was stirred for 2 hours at room temperature. After the reaction, the mixture was neutralized with 2M-hydrochloric acid and extracted with methylene chloride to obtain 820 mg of 3-trifluoromethylheptyl tosylate from the resultant methylene chloride layer. [α]D23 +0.5° (c 2, CH2Cl2), [α]43523 +2.2° (c 2, CH2Cl2)

1. customAfter the reaction
2. extractionextracted with methylene chloride