反应详情

In a round-bottomed flask, 3.3 g of (-)-3-trifluoromethyl-1-heptanol and 5.7 g of pyridine were placed and stirred, and 3.4 g of p-toluenesulfonyl chloride was added, followed by 4 hours of reaction at 15°-20° C. The reaction mixture was poured into water, acidified with hydrochloric acid and extracted with diethyl ether, followed further by drying with sodium sulfate, and distilling-off of the solvent to obtain 5.3 g of (+)-3-trifluoromethylheptyl p-toluenesulfonate.

1. customfollowed by 4 hours of reaction at 15°-20° C
2. extractionextracted with diethyl ether
3. dry with materialby drying with sodium sulfate