Ethyl heptanoate → heptanohydrazide

HRID 1461191Notes

Reaction equation

HRID 1461191 reaction equation
O.[NH2:2][NH2:3].[C:4]([O:12]CC)(=O)[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH3:10]>C(O)C>[C:4]([NH:2][NH2:3])(=[O:12])[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH3:10]

Participants

4

Reactant 2

HCID 7797Ethyl heptanoateHCID 24654Hydrazine hydrate (1:1)

Product 1

HCID 240032heptanohydrazideYield 51.2%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

12.2 g of hydrazine hydrate was added to a solution of 15 g of ethyl heptanoate in 20 ml of ethanol, followed by heat-refluxing for 4.5 hours. After the reaction, the reaction mixture was cooled to precipitate a crystal. The crystal was recovered by filtration and recrystallized from 20 ml of ethanol to obtain 7 g of heptanohydrazide.

Workup

  1. temperatureby heat-refluxing for 4.5 hours
  2. customAfter the reaction
  3. temperaturethe reaction mixture was cooled
  4. customto precipitate a crystal
  5. filtrationThe crystal was recovered by filtration
  6. customrecrystallized from 20 ml of ethanol

Sources & evidence

ORD record
ord-46b2d9783d724d0cbfad6567f034ef7a
Source dataset
uspto-grants-1991_12
Patent number
US05075030

Reaction notes

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