Kojic Acid → 4H-Pyran-4-one, 2-(hydroxymethyl)-5-[(4-methoxyphenyl)methoxy]-

HRID 1461237Notes

Reaction equation

HRID 1461237 reaction equation
[CH:1]1[C:6](=[O:7])[C:5]([OH:8])=[CH:4][O:3][C:2]=1[CH2:9][OH:10].C(=O)([O-])[O-].[K+].[K+].[CH3:17][O:18][C:19]1[CH:26]=[CH:25][C:22]([CH2:23]Cl)=[CH:21][CH:20]=1>CN(C)C=O>[CH3:17][O:18][C:19]1[CH:26]=[CH:25][C:22]([CH2:23][O:8][C:5]2[C:6](=[O:7])[CH:1]=[C:2]([CH2:9][OH:10])[O:3][CH:4]=2)=[CH:21][CH:20]=1

Participants

5

Reactant 3

HCID 3840Kojic AcidHCID 11430Potassium CarbonateHCID 699934-Methyloxybenzyl chloride

Product 1

HCID 104916984H-Pyran-4-one, 2-(hydroxymethyl)-5-[(4-methoxyphenyl)methoxy]-

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Kojic acid, 42.6 g, was dissolved in 350 ml of dimethylformamide and 82.8 g of anhydrous potassium carbonate and 55 g of p-methoxybenzyl chloride were added to the solution. The reaction was carried out at 70° to 75° C. for 1.5 hours.

Sources & evidence

ORD record
ord-fdb2f6c247cd43caa5088b6e291c81e8
Source dataset
uspto-grants-1991_12
Patent number
US05075299

Reaction notes

Loading…