反应详情

Combine 3(S)-amino-:-caprolactam (0.28 g,2.2 mmol), 2(S)-acetylthiomethyl-3-(2-methylphenyl)propionic acid (0.50 g,2.0 mmol) and hydroxybenzotriazole (HOBT) (0.33 g,2.2 mmol) in DMF (10ml). Add 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (DEC) (0.42 g,2.2 mmol). Stir 18hr, partition between EtOAc and H2O, dry and concentrate. Chromatograph on silica, eluting with diethyl ether (Et2O) to obtain the title compound as a foam,[α]D26 =-31.3° (EtOH).

1. custompartition between EtOAc and H2O
2. customdry
3. concentrationconcentrate
4. washChromatograph on silica, eluting with diethyl ether (Et2O)