Tetrahydrofuran → HCID 19980406, compound

HRID 1461336Notes

Reaction equation

HRID 1461336 reaction equation
[CH2:1]([O:3][C:4]([N:6]1[CH2:11][CH2:10][C:9]([OH:17])([CH2:12][C:13]([CH2:15]Br)=[CH2:14])[CH2:8][CH2:7]1)=[O:5])[CH3:2].[OH-].[Na+].C1COCC1>C(Cl)Cl.O>[CH2:1]([O:3][C:4]([N:6]1[CH2:11][CH2:10][C:9]2([O:17][CH2:14][C:13](=[CH2:15])[CH2:12]2)[CH2:8][CH2:7]1)=[O:5])[CH3:2]

Participants

5

Reactant 3

HCID 8028TetrahydrofuranHCID 14798Sodium HydroxideHCID 19980412HCID 19980412, compound

Product 1

HCID 19980406HCID 19980406, compound

Reagents, catalysts & solvents 1

HCID 21908982Water methylene chlorideSolvent

Procedure

The product of step b) (1.50 g, 0.0066 mmol), 50% NaOH (15 ml) and THF (20 ml) were mixed and stirred overnight. The reaction mixture was diluted with CH2Cl2 /H2O and separated. The aqueous layer was further extracted with CH2Cl2 (50 ml×2) and worked-up to give 1.42 g of a tan oil.

Workup

  1. customseparated
  2. extractionThe aqueous layer was further extracted with CH2Cl2 (50 ml×2)

Sources & evidence

ORD record
ord-1d26daba559a435ba446700a9b7c0ac7
Source dataset
uspto-grants-1991_12
Patent number
US05075317

Reaction notes

Loading…