Lithium Hydroxide → HCID 15027385, compound

HRID 1461435Notes

Reaction equation

HRID 1461435 reaction equation
[Cl:1][C:2]1[C:7]([CH3:8])=[CH:6][CH:5]=[C:4]([Cl:9])[C:3]=1[NH:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[CH:17]([CH3:20])[NH:18][OH:19].[C:21](Cl)(=[O:23])[CH3:22].C(N(CC)CC)C.[OH-].[Li+]>>[Cl:1][C:2]1[C:7]([CH3:8])=[CH:6][CH:5]=[C:4]([Cl:9])[C:3]=1[NH:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[CH:17]([N:18]([OH:19])[C:21](=[O:23])[CH3:22])[CH3:20]

Participants

5

Reactant 4

HCID 3939Lithium HydroxideHCID 6367Acetyl chlorideHCID 8471TriethylamineHCID 54337140HCID 54337140, compound

Product 1

HCID 15027385HCID 15027385, compoundYield 45%

Procedure

2-[(2,6-Dichloro-3-methylphenyl)amino]-N-hydroxy-α-methylbenzenemethanamine (1.2 g, 3.8 mmol) is reacted with acetyl chloride (0.66 g, 8.5 mmol), triethylamine (1.2 g, 11.6 mmol), and lithium hydroxide (0.46 g, 19.3 mmol) according to the procedure of Example 48 to give N-[1-[2-[(2,6-dichloro-3-methylphenyl) amino]phenyl]ethyl]-N-hydroxyacetamide (0.6 g, 45% yield); mp 185°-187° C.

Sources & evidence

ORD record
ord-d32f2b191b4e48a994fe12551b71cd12
Source dataset
uspto-grants-1991_12
Patent number
US05075330

Reaction notes

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