反应详情

5-Acetoxyacetamido-N,N'-bis[(2,3-dihydroxypropyl)-2-hydroxyethyl]-2,4,6-triiodoisophthalamide, prepared as in Example 3, Step B, (89 g, 0.1 g-mole) is mixed with K2CO3 (27.6 g, 0.2-g mole) and 2-bromoethyl acetate (33.4 g, 0.2 g-mole) in DMAc (200 ml). The mixture is stirred at 35°-40° C. until the reaction is complete (approximately 8-12 hours). The solution is then cooled to room temperature and the inorganic salts are filtered. The filtrate is then evaporated under vacuum at 70° C. to yield a thick oil. The oil is triturated with isopropyl alcohol to dissolve the residual DMAC and bromoethyl acetate. The supernatant is decanted and the residual solid is evaporated to dryness to provide the desired product.

1. custom(approximately 8-12 hours)
2. filtrationthe inorganic salts are filtered
3. customThe filtrate is then evaporated under vacuum at 70° C.
4. customto yield a thick oil
5. customThe oil is triturated with isopropyl alcohol
6. dissolutionto dissolve the residual DMAC and bromoethyl acetate
7. customThe supernatant is decanted
8. customthe residual solid is evaporated to dryness