Sodium aminomethanesulfonate → HCID 86745351, compound

HRID 1461641Notes

Reaction equation

HRID 1461641 reaction equation
[Br-].[CH2:2]([NH2+:14][CH2:15][C:16]([OH:19])([OH:18])[OH:17])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH3:13].[NH2:20][CH2:21][S:22]([O-:25])(=[O:24])=[O:23].[Na+]>C(O)(C)C>[NH2:20][CH2:21][S:22]([O-:25])(=[O:24])=[O:23].[CH2:2]([NH2+:14][CH2:15][C:16]([OH:19])([OH:17])[OH:18])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH3:13]

Participants

4

Reactant 2

HCID 23667279Sodium aminomethanesulfonateHCID 86745352HCID 86745352, compound

Product 1

HCID 86745351HCID 86745351, compoundYield 92.6%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

A four-necked flask fitted with stirrer and condenser means was charged with 39.8 g of lauryltrihydroxyethylammonium bromide, 15.9 g of sodium aminomethanesulfonate and 200 g of isopropyl alcohol and the reaction was conducted at 70°-80° C. in an atmosphere of nitrogen gas introduced at a low flow rate for 5 hours. The precipitate was then filtered off and the filtrate was concentrated. The residue was dissolved in 200 g of isopropyl alcohol and the insolubles were filtered off. Finally, the filtrate was concentrated to give 40.1 g (theoretical yield 42.8 g) of lauryltrihydroxyethylammonium aminomethanesulfonate as a waxy product. The elemental analysis is shown below.

Workup

  1. customA four-necked flask fitted with stirrer and condenser means
  2. customwas conducted at 70°-80° C. in an atmosphere of nitrogen gas
  3. additionintroduced at a low flow rate for 5 hours
  4. filtrationThe precipitate was then filtered off
  5. concentrationthe filtrate was concentrated
  6. dissolutionThe residue was dissolved in 200 g of isopropyl alcohol
  7. filtrationthe insolubles were filtered off
  8. concentrationFinally, the filtrate was concentrated

Sources & evidence

ORD record
ord-565417762b40452b9dc82555443f1375
Source dataset
uspto-grants-1991_12
Patent number
US05076828

Reaction notes

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