反应详情

A solution of 4-pentafluoroethylpyrimidin-6-one (0.4 g) and N-chlorosuccinimide (0.27 g) in dry dimethylformamide (5 ml) was heated to 80° C. for 3 hours. After cooling to ambient temperature, the reaction mixture was poured into water, and extracted into ethyl acetate. The organic layer was dried, over anhydrous magnesium sulphate, filtered, and evaporation of the solvent under reduced pressure gave a brown oil. Recrystallisation from water gave 5-chloro-4-pentafluoroethylpyrimidin-6-one

1. extractionextracted into ethyl acetate
2. dry with materialThe organic layer was dried, over anhydrous magnesium sulphate
3. filtrationfiltered
4. customevaporation of the solvent under reduced pressure
5. customgave a brown oil
6. customRecrystallisation from water