Methyl 4-(4-oxocyclohexyl)benzoate → 2-Carbomethoxy-4-(4'-carbomethoxyphenyl)cyclohexanone

HRID 1461792Notes

Reaction equation

HRID 1461792 reaction equation

[C:1]([C:5]1[CH:10]=[CH:9][C:8]([CH:11]2[CH2:16][CH2:15][C:14](=[O:17])[CH2:13][CH2:12]2)=[CH:7][CH:6]=1)([O:3][CH3:4])=[O:2].[CH3:18][O:19][C:20](=O)[O:21]C.[H-].[Na+]>C1COCC1>[C:20]([CH:15]1[CH2:16][CH:11]([C:8]2[CH:9]=[CH:10][C:5]([C:1]([O:3][CH3:4])=[O:2])=[CH:6][CH:7]=2)[CH2:12][CH2:13][C:14]1=[O:17])([O:19][CH3:18])=[O:21]

Participants

4

Reactant 2

HCID 15023908Methyl 4-(4-oxocyclohexyl)benzoate

HCID 86745363dimethylcarbonate NaH

Product 1

HCID 157192002-Carbomethoxy-4-(4'-carbomethoxyphenyl)cyclohexanoneYield 63%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Compound 14 was acylated with dimethylcarbonate/NaH/-KH in THF to give 15 (63%).

Sources & evidence

ORD record: ord-26520cd213d4445daa2dd0612026a836
Source dataset: uspto-grants-1991_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05077404

Reaction notes

Loading…