Tert-Butylamine → HCID 19979631, compound

HRID 1461811Notes

Reaction equation

HRID 1461811 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([O:8][C:9]2[S:10][CH:11]=[C:12]([Br:14])[N:13]=2)[CH:5]=[C:4]([CH3:15])[C:3]=1[N:16]=[C:17]=[S:18].[C:19]([NH2:23])([CH3:22])([CH3:21])[CH3:20]>O1CCCC1>[CH3:1][C:2]1[CH:7]=[C:6]([O:8][C:9]2[S:10][CH:11]=[C:12]([Br:14])[N:13]=2)[CH:5]=[C:4]([CH3:15])[C:3]=1[NH:16][C:17]([NH:23][C:19]([CH3:22])([CH3:21])[CH3:20])=[S:18]

Participants

4

Reactant 2

HCID 6385Tert-ButylamineHCID 19979630HCID 19979630, compound

Product 1

HCID 19979631HCID 19979631, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

2.1 g of 2,6-dimethyl-4-(4-bromothiazol-2-yloxy)-phenylisothiocyanate and 0.7 g of tert-butylamine in 20 ml tetrahydrofuran are heated for 6 hours to 40° C. The batch is poured into 200 ml of ice-water and the precipitate is isolated by filtration. Recrystallisation of the precipitate from methanol affords the title compound of formula ##STR24## in crystalline form with a melting point of 143°-144° C. (compound 3.01).

Workup

  1. customthe precipitate is isolated by filtration
  2. customRecrystallisation of the precipitate from methanol

Sources & evidence

ORD record
ord-fa396b409de1479981cc200a6c1fcb1c
Source dataset
uspto-grants-1991_12
Patent number
US05077412

Reaction notes

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