1-Methylpiperazine → HCID 13324579, compound

HRID 1461965Notes

Reaction equation

HRID 1461965 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.[C:8]([C:10]1[CH:11]=[CH:12][C:13]([OH:24])=[C:14]([CH:23]=1)[NH:15][C:16](=[O:22])[C:17]([O:19]CC)=O)#[N:9]>CO>[C:8]([C:10]1[CH:11]=[CH:12][C:13]([OH:24])=[C:14]([CH:23]=1)[NH:15][C:16](=[O:22])[C:17]([N:5]1[CH2:6][CH2:7][N:2]([CH3:1])[CH2:3][CH2:4]1)=[O:19])#[N:9]

Participants

4

Reactant 2

HCID 531671-MethylpiperazineHCID 13324573HCID 13324573, compound

Product 1

HCID 13324579HCID 13324579, compoundYield 81.2%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a mixture of 1.2 g of N-methylpiperazine and 20 ml of methanol was added gradually 2 g of ethyl 5-cyano-2-hydroxyoxanilate and after stirring the mixture for 3 hours at room temperature, crystals formed were recovered by filtration, washed successively with isoporpnaol and ether, and dried to provide 2 g of 1-(5-cyano-2-hydroxyoxanilyl)-4-methylpiperazine.

Workup

  1. customcrystals formed
  2. filtrationwere recovered by filtration
  3. washwashed successively with isoporpnaol and ether
  4. customdried

Sources & evidence

ORD record
ord-6cec82cde6f34e3d92e9a26d2996fc3c
Source dataset
uspto-grants-1984_07
Patent number
US04457872

Reaction notes

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