Hydrochloric Acid → 2,6-Difluorobenzoyl isocyanate

HRID 1462012Notes

Reaction equation

HRID 1462012 reaction equation
C(Cl)(=O)[C:2](Cl)=[O:3].[F:7][C:8]1[CH:16]=[CH:15][CH:14]=[C:13]([F:17])[C:9]=1[C:10]([NH2:12])=[O:11].Cl.[C]=O>C1(C)C=CC=CC=1>[F:7][C:8]1[CH:16]=[CH:15][CH:14]=[C:13]([F:17])[C:9]=1[C:10]([N:12]=[C:2]=[O:3])=[O:11]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 65578Oxalyl chlorideHCID 874392,6-DifluorobenzamideHCID 178418416HCID 178418416, compound

Product 1

HCID 27333692,6-Difluorobenzoyl isocyanate

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

Twenty-eight grams (0.22 mol) of oxalyl chloride were added dropwise to a solution of 31.4 gm (0.20 mol) of 2,6-difluorobenzamide in 250 ml of toluene. The solution thus obtained was boiled under reflux for five hours, during which time hydrogen chloride and carbon monoxide were liberated. The solvent was then distilled off, in vacuo at the end. The product which remained was distilled in an oil pump vacuum.

Workup

  1. customThe solution thus obtained
  2. distillationThe solvent was then distilled off, in vacuo at the end
  3. distillationThe product which remained was distilled in an oil pump vacuum

Sources & evidence

ORD record
ord-31c778896890488d8c9837a080a34b0c
Source dataset
uspto-grants-1984_07
Patent number
US04457943

Reaction notes

Loading…