Piperidine → HCID 13345145, compound

HRID 1462026Notes

Reaction equation

HRID 1462026 reaction equation
[CH2:1]([O:3][C:4]([N:6]1[CH2:11][CH2:10][N:9]([CH2:12][CH2:13]Cl)[CH2:8][CH2:7]1)=[O:5])[CH3:2].[NH:15]1[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]1.C(=O)([O-])[O-].[K+].[K+].C1(N)C(F)=C(F)C(F)=C(N)C=1F.Cl.Cl>C(O)C.CO>[N:15]1([CH2:13][CH2:12][N:9]2[CH2:10][CH2:11][N:6]([C:4]([O:3][CH2:1][CH3:2])=[O:5])[CH2:7][CH2:8]2)[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]1

Participants

7

Reactant 4

HCID 8082PiperidineHCID 11430Potassium CarbonateHCID 149026Tetrafluoro-m-phenylenediamine dihydrochlorideHCID 201594Ethyl 4-(2-chloroethyl)piperazine-1-carboxylate

Product 1

HCID 13345145HCID 13345145, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 887MethanolSolvent

Procedure

By reaction of 1-(ethoxycarbonyl-4-(2-chloroethyl)-piperazine (11.05 grams; 0.05 moles), piperidine (4.3 grams; 0.05 moles) and potassium carbonate (7.0 grams; 0.05 moles) in 150 cc of ethanol by boiling until disappearance of the reactants by TLC (methanol), a product is obtained which is identical to the product described in Example 13 as shown by boiling point, melting point, mixed melting point of the dihydrochloride; Rf and IR.

Workup

  1. customa product is obtained which
  2. additionmixed

Sources & evidence

ORD record
ord-88e457dbfcab46e3ab5bcc24cc8069ca
Source dataset
uspto-grants-1984_07
Patent number
US04457931

Reaction notes

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