Water → HCID 14925797, compound

HRID 1462124Notes

Reaction equation

HRID 1462124 reaction equation
[N:1]1[C:8]([Cl:9])=[N:7][C:5](Cl)=[N:4][C:2]=1[Cl:3].[F:10][C:11]([F:15])([F:14])[CH2:12][NH2:13].C(N(CC)CC)C.O>CC(C)=O>[Cl:9][C:8]1[N:1]=[C:2]([Cl:3])[N:4]=[C:5]([NH:13][CH2:12][C:11]([F:15])([F:14])[F:10])[N:7]=1

Participants

6

Reactant 4

HCID 962WaterHCID 7954Cyanuric chlorideHCID 8471TriethylamineHCID 9773Ethanamine, 2,2,2-trifluoro-

Product 1

HCID 14925797HCID 14925797, compoundYield 45%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

166 g (0.9 mol) of cyanuric chloride were dissolved in 1 liter of warm acetone, the solution was filtered off from the small quantity of insoluble substance, and a solution of 90 g (0.9 mol) of 2,2,2-trifluoroethylamine in 101 g (1.0 mol) of triethylamine was added dropwise at 0° to 5° C., while stirring and cooling with ice. The mixture was stirred for some time, approx. 1 liter of water was added, and the crystals which had formed were filtered off under suction. After the product had been dried, 100 g (=45% of theory) of 2,4-dichloro-6-(2,2,2-trifluoroethylamino)-s-triazine of melting point 115° to 118° C. were obtained.

Workup

  1. filtrationthe solution was filtered off from the small quantity of insoluble substance
  2. temperaturecooling with ice
  3. additionwas added
  4. customthe crystals which had formed
  5. filtrationwere filtered off under suction
  6. customAfter the product had been dried

Sources & evidence

ORD record
ord-4c9c91e80674438caaff25ef6fca89ad
Source dataset
uspto-grants-1984_07
Patent number
US04459151

Reaction notes

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