Propylamine → HCID 13336929, compound

HRID 1462294Notes

Reaction equation

HRID 1462294 reaction equation
[C:1]([C:3]1[C:8]([C:9]#[N:10])=[N:7][C:6](Cl)=[C:5]([CH2:12][CH:13]([CH3:15])[CH3:14])[N:4]=1)#[N:2].[CH2:16]([NH2:19])[CH2:17][CH3:18].[OH-].[Na+]>O1CCCC1>[C:1]([C:3]1[C:8]([C:9]#[N:10])=[N:7][C:6]([NH:19][CH2:16][CH2:17][CH3:18])=[C:5]([CH2:12][CH:13]([CH3:15])[CH3:14])[N:4]=1)#[N:2]

Participants

5

Reactant 3

HCID 7852PropylamineHCID 14798Sodium HydroxideHCID 12907203HCID 12907203, compound

Product 1

HCID 13336929HCID 13336929, compoundYield 85.5%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

2,3-Dicyano-5-chloro-6-isobutylpyrazine (1.10 g; 0.005 mole) was dissolved in 20 ml of tetrahydrofuran. The solution was worked up in the same way as in Example 13 using 0.30 g (0.005 mole) of n-propylamine and 0.02 g (0.005 mole) of sodium hydroxide to afford 1.04 g (yield 85%) of 2,3-dicyano-5-n-propylamino-6-isobutylpyrazine.

Sources & evidence

ORD record
ord-ee58e8bf41534a7e8f8c0789edd57762
Source dataset
uspto-grants-1984_07
Patent number
US04460403

Reaction notes

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