Phosphorus oxychloride → Ethyl 2-[2-phenyl-5-(2-thienyl)-4-oxazolyl]acetate

HRID 1462400Notes

Reaction equation

HRID 1462400 reaction equation
[C:1]([NH:9][CH:10]([C:17]([C:19]1[S:20][CH:21]=[CH:22][CH:23]=1)=[O:18])[CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13])(=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.P(Cl)(Cl)(Cl)=O>CN(C)C=O>[C:2]1([C:1]2[O:18][C:17]([C:19]3[S:20][CH:21]=[CH:22][CH:23]=3)=[C:10]([CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13])[N:9]=2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 13105424Ethyl 3-benzoylamino-3-(2-thienylcarbonyl)propionate

Product 1

HCID 13105455Ethyl 2-[2-phenyl-5-(2-thienyl)-4-oxazolyl]acetateYield 79%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

1.5 g of ethyl 3-benzoylamino-3-(2-thienylcarbonyl)propionate, 10 ml of dimethylformamide and 0.5 g of phosphorus oxychloride are treated in the same manner as described in Example 1. 1.1 g of ethyl 2-[2-phenyl-5-(2-thienyl)-4-oxazolyl]acetate are thereby obtained.

Sources & evidence

ORD record
ord-1678c5d1ad4741a1acf0e4f1be46ec07
Source dataset
uspto-grants-1984_07
Patent number
US04460596

Reaction notes

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