Phosphorus oxychloride → HCID 13105456, compound

HRID 1462401Notes

Reaction equation

HRID 1462401 reaction equation
[F:1][C:2]1[CH:24]=[CH:23][C:5]([C:6]([NH:8][CH:9]([C:16]([C:18]2[S:19][CH:20]=[CH:21][CH:22]=2)=[O:17])[CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])=O)=[CH:4][CH:3]=1.P(Cl)(Cl)(Cl)=O>CN(C)C=O>[F:1][C:2]1[CH:24]=[CH:23][C:5]([C:6]2[O:17][C:16]([C:18]3[S:19][CH:20]=[CH:21][CH:22]=3)=[C:9]([CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])[N:8]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 13105425HCID 13105425, compound

Product 1

HCID 13105456HCID 13105456, compoundYield 74.8%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

38.6 g of ethyl 3-(4-fluorobenzoylamino)-3-(2-thienylcarbonyl)propionate, 100 ml of dimethylformamide and 20.3 g of phosphorus oxychloride are treated in the same manner as described in Example 1. 27.4 g of ethyl 2-[2-(4-fluorophenyl)-5-(2-thienyl)-4-oxazolyl]acetate are thereby obtained.

Sources & evidence

ORD record
ord-0bbb328dca084f28a9aaf2e73176ff5a
Source dataset
uspto-grants-1984_07
Patent number
US04460596

Reaction notes

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